HOT mutation screening in human glioblastomas
نویسندگان
چکیده
منابع مشابه
HOT mutation screening in human glioblastomas
AIMS Somatic mutations in IDH1 and IDH2 are described in glioblastomas (GBMs). Mutant IDH1 and IDH2 reduce α-KG to D-2HG which accumulates, and is proposed to promote tumorigenesis. HOT catalyzes the conversion of γ-hydroxybutyrate to succinic semialdehyde in a reaction that produces D-2HG. Since increased HOT enzyme activity could lead to an accumulation of D-2HG, coupled with the fact that on...
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ژورنال
عنوان ژورنال: Future Science OA
سال: 2015
ISSN: 2056-5623
DOI: 10.4155/fso.15.20